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Abstract Background Retatrutide is a novel triple agonist targeting the receptors of glucagon-like peptide 1 (GLP-1), gastric inhibitory polypeptide (GIP), and glucagon

Participants achieved substantial average total weight loss, often ranging from 15% to over 25% of their starting body weight by the end of the study period

This suppresses appetite and promotes feelings of fullness, leading to reduced calorie intake for weight management

To meet surging demand for its cardiometabolic medicines, Lilly is undertaking one of the largest manufacturing expansions in the pharmaceutical industry, committing over $50 billion in US production investments since 2020 and building multiple new facilities focused on active pharmaceutical ingredient (API) production and small-molecule synthesis