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Yerba mate's caffeine content can temporarily increase heart rate and energy expenditure, though the effect diminishes with regular consumption due to caffeine tolerance

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Depression is related to impairments due to neurogenesis, principally in the hippocampus, as well as neuronal atrophy and a decreased volume of several neuronal areas, such as the hippocampus, cortex, and limbic lobe regions of the brain

Patch-clamp electrophysiological recordings in brain slices further demonstrated that chemogenetic activation selectively depolarizes neuronal membrane potential and increases the firing frequency of labeled medulla pre-proglucagon-producing neurons without affecting unlabeled neurons

We are currently monitoring for these to occur in the Ozempic MDL