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The split between the two is the entire game
Alm de seus efeitos metablicos, a metformina tem demonstrado propriedades neuroprotetoras relevantes, mediadas principalmente pela ativao da AMPK (protena quinase ativada por monofosfato de adenosina)

Once-weekly dulaglutide versus bedtime insulin glargine, both in combination with prandial insulin lispro, in patients with type 2 diabetes (AWARD-4): a randomised, open-label, phase 3, non-inferiority study
