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Optimal dose of tirzepatide for type 2 diabetes mellitus: A meta-analysis and trial sequential analysis

Wolters Kluwer/Lippincott Williams & Wilkens, 2009, pp 375387

Subsequently, in the large randomised placebo-controlled FIDELIO-DKD trial including adults with type 2 diabetes and CKD, finerenone reduced the risk of the primary kidney outcome (a composite of kidney failure, sustained eGFR decline 40% or kidney death) by ~20% [69]

In addition, GLP-1 and its own receptors are synthesized in the same brain regions, strongly supporting the actions of this peptide on the CNS

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