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Outcomes are illustrated in Supplementary Table S5 and Supplementary Fig

Patients should contact their GP or healthcare provider if they experience no bowel movement for more than seven days despite using laxatives, as this may indicate severe constipation or faecal impaction requiring medical intervention

This is particularly true for patients who were started on insulin early in their disease course when their beta cells still had significant function, gained weight on insulin therapy, have A1C levels that might respond to GLP-1-mediated insulin secretion, or want the cardiovascular and weight loss benefits that GLP-1 medications offer

Use of insulin or sulfonylureas (risk of low blood sugardoses may need adjustment)

Beyond objective clinical outcomes, GI motility disturbances can substantially affect patient-reported outcomes, including daily functioning, dietary intake, and overall quality of life