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Incretin-based medications mimic the actions of natural incretins, such as GLP-1 and gastric inhibitory hormone (GIP)

Preclinical and clinical studies have uncovered several gastrointestinal effects of metformin, including stimulation of the incretin hormone glucagon-like peptide-1 (GLP-1) [8], slowing of gastric emptying [8], suppression of intestinal glucose absorption [9], inhibition of bile acid resorption [10, 11] and modulation of the gut microbiota [12]

GLP-1RAs have been correlated with a decreased risk of hepatic decompensation and liver cancer, with this protective effect being more significant in patients who do not have alcohol or tobacco use disorders as compared to those who do [42]

Over time, this supports improved glycemic control, reduced appetite intensity, and gradual, sustainable weight reduction when paired with consistent lifestyle habits

And they say Weight Watchers is actually trying to pivot into special Ozempic meals