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Today, we shared new data from the latest Phase 3 study of retatrutide, an investigational treatment being studied for adults with obesity or overweight with at least one weight-related comorbidity

In a new study, published in Neurology , medications commonly used to manage type 2 diabetes were associated with a reduced risk of epilepsy among study participants

Baseline estimated renal function was normal (eGFR 90 mL/min/1.73m2) in 57.2%, mildly impaired (eGFR 60 to 90 mL/min/1.73m2) in 35.9% and moderately impaired (eGFR 30 to 60 mL/min/1.73m2) in 6.9% of patients

These effects are closely related to the activation of GLP-1 receptors in both central and peripheral pathways, often leading to reduced treatment adherence or even discontinuation, which can compromise therapeutic outcomes (Tobaiqy, 2024)

But one active clinical trial, registered as NCT07092605 on ClinicalTrials.gov, is now specifically studying the effectiveness of microdosed GLP-1 receptor agonists for improving health and quality of life in patients who do not meet traditional prescribing criteria