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doi: 10.1093/ckj/sfz137

GLP-1 (7-36) amide and GLP-1 (7-37) are active form and these peptides are dissolved in blood by DDP4 (dipeptidyl peptidase-4) into GLP-1 (9-36) amide and GLP-1 (9-37) and these peptides lose its activities in short period

Theres an adjustment phase

One study found that weekly treatment with semaglutide, a GLP-1 RA, reduced the risk of a combination of stroke, heart attack, and death from cardiovascular causes by 20% compared with placebo.

Liraglutide Attenuates Preestablished Atherosclerosis in Apolipoprotein E-Deficient Mice via Regulation of Immune Cell Phenotypes and Proinflammatory Mediators