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GLP-1 agonists were approved by the FDA for diabetes treatment back in 2005so the class of drugs itself isnt new
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Therefore, while the blood pressurelowering effects seen with GLP-1 therapy are not dramatic, they are biologically consistent and clinically meaningful when considered as part of a broader cardiometabolic strategy
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Lixisenatide is cleared by glomerular filtration, followed by tubular reabsorption and subsequent metabolic degradation (126)
