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Semaglutide has a notably long half-life (7 days) compared to shorter-acting GLP-1 agonists, which means your transition period is more gradual and may involve less dramatic appetite rebound

Individuals who are pregnant, nursing, or managing certain thyroid conditions should consult a physician before pursuing GLP-1 therapy of any kind

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Given the heterogeneity in study populations and the predominance of post hoc analyses, further prospective research is essential to clarify these mechanisms and to evaluate whether personalized, sex-specific approaches to GLP-1 RA therapy could improve obesity treatment outcomes