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Description
2021;2(5):e26374
In rats, GLP-1 (7-36amide) and, perhaps paradoxically, the GLP-1R antagonist exendin (939), dose-dependently cause relaxation of the aorta, potentially via elevation of cAMP formation and activation of K ATP channels [624]

In the UK and the US, that means a BMI of 30 or more, or 27 if you also have a weight-related condition like high blood pressure or type 2 diabetes
This is well established with insulin and is considered a relevant concern for subcutaneous peptide injections more broadly
The Future The proven health benefits of GLP-1 receptor agonists (GLPRAs), like liraglutide (Saxenda) and semaglutide (Wegovy), have transformed the treatment of metabolic disease and its discovery has stimulated development of other GLP-1(7-37)-based therapeutic approaches, including an oral GLPRA, which has shown efficacy (1)
