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The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop groxup

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When Injection Site Reactions Require Provider Guidance Mild localized redness, warmth, or brief burning is expected and typically does not require medical intervention

showed that the administration of the SGLT2i empagliflozin for 4 weeks, (compared to a control group), reduced fat mass, leading to morphological changes in adipose tissue, specifically an increase in the number of small and medium-sized adipocytes and a reduction in the number of large adipocytes [82], an indirect sign of browning [25]

In addition, previous study has shown that in patients with T2DM, the effect of semaglutide is slightly lower than that in patients without diabetes [51], indicating that individualized management strategies may enhance the therapeutic effect of semaglutide