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Tirzepatide produced even more dramatic results in the SURMOUNT clinical trials, stretching the limits of what medication can do

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Since the different agonists/compounds, all of which stimulate Gs recruitment to the GIP receptor, have distinct pharmacology, they may affect interaction of the various effector molecules with the GIP receptor differently (39, 42) ( Figure 2 )

However, when used in combination, they might make us more susceptible to side effects that could impact quality of life