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Description
"Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor"
4 Receptor binding activates adenylate cyclase causing intracellular accumulation of cyclic adenosine monophosphate (cAMP), which activates protein kinase A (PKA) and triggers insulin secretion
Based on the earlier discussed receptor expression, innervation and their crucial role in behavioral control two mesolimbic nuclei, the VTA and the NAc, became the first targets of studies exploring behavioral consequences of the mesolimbic GLP-1R activation
Regulatory nods for Wegovy in Mexico and Brazil widen eligibility to millions of high-BMI adults, while cardiovascular-outcome data support use in secondary prevention
Some companies also file additional patents for things like delivery methods or dosing schedules to extend exclusivity even further
