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In 2024, the FDA expanded the label to include reducing the risk of major cardiovascular events in adults with established cardiovascular disease and overweight or obesity based on the SELECT trial, which randomized 17,604 patients and showed a 20% reduction in major adverse cardiovascular events over a mean 40 months

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In December 2023, Eli Lilly and Company, one of the major GLP-1 receptor agonist companies, announced the availability of Zepbound (tirzepatide) injection, a GLP-1 drug, in the U.S

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