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Importantly, studies that enhanced BCAA catabolism, such as through the inducible knockout or pharmacological inhibition of BCKDK (a key negative regulator), successfully blunted diastolic dysfunction, cardiac hypertrophy, and myocardial Remodelling in mice with HFpEF 93,95

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"Efficacy and Safety of Semaglutide Once-weekly Versus Sitagliptin Once-daily as add-on to Metformin and/or TZD in Subjects With Type 2 Diabetes (SUSTAIN 2)"