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Together, these findings indicate that leptin signaling is a critical permissive factor for mitochondrial efficiency improvements during semaglutide-induced weight loss

The incretin peptides GLP-1 (glucagon-like peptide 1) and GIP (glucose-dependent insulinotropic polypeptide), which are the gut derived hormones secreted by L cells and K cells, respectively, after nutrient ingestion, are blood glucose-lowering hormones that potentiate insulin secretion in response to glucose [5]

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