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Although limited, the evidence suggests that combined therapy has an enhanced effect in reducing cardiovascular events in selected populations and positively impacting important surrogate kidney disease markers

Even if fragments reach the surface, epithelial tight junctions (TJs) restrict the paracellular route to tiny pores

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It is for those with multiple cardiovascular risk factors or established cardiovascular disease as an adjunct to diet, exercise, and standard-of-care therapy

If side effects are severe (persistent vomiting, signs of pancreatitis, vision changes), stop the medication and contact your prescriber immediately