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This has led to a surge of interest in using GLP-1s as so-called anti-ageing miracles, with proponents suggesting that their positive effects on blood sugar, appetite regulation, and cardiovascular health may help promote healthier ageing

Robert Kushner: I haven't seen that paper, but what I can say which I thought you were getting to is that when we look at the categorical weight loss in all these trials, so some people lose 5%, 10%, 20%, 25% over the course of the trial, if you then stop the medication, the individuals who lost the greatest amount of body weight actually are the ones that regain it the quickest

d PIONEER, 6 was designed to document cardiovascular safety only

Supplementary material The Supplementary Material for this article can be found online at: References 1 VestergaardP

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