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For the treatment regimen estimand, all tirzepatide doses were associated with numerically higher odds of participants with prediabetes achieving reversal versus liraglutide and semaglutide (Supplementary Material Table S8), although the higher proportion of patients with prediabetes achieving reversal in the placebo arm of SURMOUNT-1 compared with SCALE and STEP 1 suggests that the relative efficacy of tirzepatide versus liraglutide and semaglutide may be underestimated (Supplementary Material Table S4)

By 72 weeks, the difference is substantial: 22.5 percent body weight loss for tirzepatide 15 mg versus approximately 15 to 16 percent for semaglutide 2.4 mg

Hormone-sensitive lipase breaks these triglycerides into free fatty acids and glycerol, releasing them into the bloodstream

Further, the PI3K/Akt/GSK-3 signaling pathway regulates mitochondrial complex I activity, which is essential for mitochondrial function, energy metabolism, and redox balance (Rai et al., 2019)
