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analysis [37], patients on GLP-1 RAs (exenatide, lixisenatide, semaglutide, dulaglutide, liraglutide, tirzepatide) had a significantly lower 1-year shunt placement rate (OR 0.375, 95% CI 0.1710.753, p = 0.047)

The medication also reduces dopamine signaling in the brain's reward center

A post hoc analysis of the phase IIb trial showed that tirzepatide was associated with a reduction in the level of high-sensitivity ICAM-1, CRP, and YKL-40 after 26 weeks of treatment in a dose-dependent manner [83, 103]

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The oral formulation may have different absorption characteristics that influence gastrointestinal tolerability. Saxenda (Liraglutide): Shows a 13% reduction in gastric emptying at the 1-hour mark with lower doses compared to semaglutide, potentially causing fewer burping issues Dose adjustments: Working with your healthcare provider to find the optimal dose that balances efficacy with tolerability can help manage side effects Other medications in the GLP-1 class may have different side effect profiles, and your healthcare provider can help determine the best option based on your individual response and health goals