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Given that the glucose-lowering effect of metformin is so strong and is independent of incretin signalling, it might be difficult to detect the beneficial effect of metformin on the incretin axis in human studies

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Your eating habits, physical activity level, and hydration can impact how well you respond to treatment

Cardiovascular Benefits : Some GLP-1 receptor agonists have shown to reduce the risk of cardiovascular events like heart attacks and strokes in people with type 2 diabetes

Evaluating the gastrointestinal tolerability of semaglutide in type 2 diabetes management: A randomized, placebo-controlled trial. Journal of Diabetes Research and Clinical Metabolism, 13(2), 345-356