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Nerve damage from repeated injections at the same site causes tingling, numbness, or burning sensationsthese symptoms require prompt evaluation
Another indicator of this phenomenon is that in Primes study, patients without type 2 diabetes discontinued treatment at a higher rate than those with the disease

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This makes individuals with Crohn's potentially more vulnerable to medications that affect gastrointestinal function, including those that slow gastric emptying or alter bowel motility
