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N Engl J Med 2012;366:1577-85

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Also, enlarged EAT predicts an increased risk of adverse outcomes in patients with HFpEF, regardless of BMI [102, 103]

It has become a valuable tool in various stages of drug development, including first-in-human dose calculation, predicting DDI potential, and assessing pharmacokinetic profiles in special populations such as pediatrics and patients with renal or hepatic impairment

They know what to expect, and that firsthand understanding helps patients feel supported rather than overwhelmed