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At the time, prescribers were warned to only use the drugs for their licensed indication and to avoid initiating GLP-1 RAs for T2DM patients during the shortage

Chemical modifications, such as amino acid mutations, addition of fatty acid chains, or design of synthetic analogs, can enhance their resistance to enzymatic degradation and significantly improve metabolic stability and half-life (Yu et al., 2018

Patient satisfaction data reveals different strengths for each platform, with Noom Med scoring higher for app usability and Calibrate receiving better ratings for medical care quality

Common ones include: Nausea, vomiting, diarrhea and bloating Constipation, which can lead to complications, if not managed Loss of muscle mass, slowing metabolism and making weight maintenance harder Weight cycling, where stopping the medication causes rapid weight gain Among these, chronic constipation is a persistent issue