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PKA-mediated induction of IRS-2 expression also promotes -cell growth in response to GLP-1, 53,62 and PKA mediates the action of GLP-1 to promote translocation of transcription factor PDX-1 to the nucleus, thereby enhancing the differentiated state of -cells

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The SGLT2i treated cohort showed preservation of eGFR over a 5-year period compared with the GLP-1 RA treated cohort (+3.5 ml/min per 1.73 m 2 vs 7.2 ml/min per 1.73 m 2 , respectively), including patients with established chronic kidney disease (CKD)