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In clinical trials, medications such as semaglutide, liraglutide, and tirzepatide consistently produce significant weight loss
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There is variability across drugs [169,170,171,172]
Although liraglutide also reduced fibrosis progression, improvements in fibrosis scores were not statistically significant
This unique mechanism is designed to combine the incretin effects of GLP-1 and GIP with the energy-expenditure benefits of glucagon receptor activation, thereby potentially achieving greater weight reduction and metabolic improvements compared with single- or dual-agonist therapies
