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This case underscores the importance of physician awareness and patient education regarding potential severe gastrointestinal side effects associated with tirzepatide, even at low doses.

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the endocytic adaptor Epsin binds to the ubiquitinated intracellular domain, and the resulting Clathrin-mediated endocytosis exerts a pulling force that exposes the cleavage site in the NRR [[4][4][6][5]]