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Key regulatory requirements include validating its sequence, verifying purity, assessing structural integrity, and conducting stability testing

It is currently approved only for type 2 diabetes mellitus (Mounjaro) and chronic weight management (Zepbound), and any potential addiction-related benefits remain investigational

Avicenna J

doi: 10.3389/fendo.2026.1758848 Received 02 December 2025 Revised 19 January 2026 Accepted 21 January 2026 Published 09 February 2026 Volume 17 - 2026 Edited by Antonio Rossi, University of Milan, Italy Reviewed by Juraj Stanik, Comenius University, Slovakia Kishore Shil, Khulna Medical College Hospital, Bangladesh Updates Copyright 2026 Dikranian, Hadara and Lysy

Overcoming Metabolic Adaptation When you fast naturally, your body often lowers its basal metabolic rate to "save" energy
