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And none of the big GLP-1 trials studied anything like microdosing. So right away, if youre going off-label, youre stepping into the unknown. Heres a quick rundown of what might drive someone to try a less-is-more approach: Cost concerns: Depending on your insurance (or lack thereof), these medications can be pricy

Liraglutide modulates gut microbiota and reduces NAFLD in obese mice

Nally LM, Sherr JL, Van Name MA, Patel AD, Tamborlane WV (2019) Pharmacologic treatment options for type 1 diabetes: whats new

GLP-2 and GIP exert separate effects on bone turnover: A randomized, placebo-controlled, crossover study in healthy young men

and, for Medicare beneficiaries, drugs like Wegovy and Zepbound will be covered for obesity under certain conditions and beneficiaries will pay just $50 per month in co-pays