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The biggest disadvantage is cost, since sitagliptin is approximately three times more expensive than metformin and about ten times more expensive than the sulfonylureas

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Thyroid nodules in patients on tirzepatide warrant careful monitoring

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A phase 1b randomised controlled trial of a glucagon-like peptide-1 and glucagon receptor dual agonist IBI362 (LY3305677) in Chinese patients with type 2 diabetes

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Indeed, obesity, often present in people with T2D, is also a major risk factor for CKD development (4), as are associated conditions such as elevated blood pressure and dyslipidemia

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Potential Side Effects The GLP-1 receptor agonists type medications interfere with absorption and utilization of vitamins and minerals in the body which may lead to nutrient depletion, loss of muscle mass and changes in facial appearance

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