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The nausea is directly caused by slowed gastric emptying
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Tirzepatide primarily functions by regulating appetite, improving insulin sensitivity, and supporting weight loss through GLP-1 and GIP receptor activation
Desensitization of GIPR by GIPR agonism, however, seems to be restricted to GIP effects on the islets, and does not occur for GIP's effect on CNS-mediated food intake suppression [1037]
