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Evidence for Cardiovascular Safety The DPP-4 inhibitors have not demonstrated any sustained or clinically significant reduction in other cardiovascular risk factors, such as blood pressure or lipids

Lipolysis was also evident by an increase in glycerol released to the medium in eWAT explants from mice treated with G49 and sacrificed after 6 h and confirmed by ex vivo treatment of eWAT explants from DIO mice with G49 (500 nM) for 4 h (Fig