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Unlike many clinical end points, weight loss is directly observable to patients, which may result in informative censoring, with those observing no weight loss being more likely to discontinue or switch drugs

Compare that to drawing 12.5 units for the same 2.5mg dose from a 20mg/ml vial, where even a tiny measurement error represents a significant percentage of the total dose

But the mechanism behind it tells a completely different story than most people assume, and understanding that mechanism is the difference between panicking unnecessarily and taking targeted action that actually works

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