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Indeed, by comparing the high-dose liraglutide therapy (3.0 mg/day) with the combination therapy (metformin 1000 mg BID + liraglutide 1.2 mg/day), Jensterle et al
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Therefore, the functional domains responsible for currently discovered function of DPP-4 are all located in the extracellular portion and the functions of intracellular domain of DPP-4 remain elusive
