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This mutation causes inappropriately increased intestinal iron absorption at a rate 23 times greater than normal.8 Similar to type 1 diabetes being a metabolic condition of glucose homeostasis due to insulin deficiency, HH is a metabolic condition of iron homeostasis due to hepcidin deficiency

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By activating GLP-1, GIP, and glucagon receptors, it could increase overall calorie burning, improve how sugars and fats are processed after meals, support steadier blood glucose levels, and gradually reduce fat mass

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