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J., & Al Khalili, Y

The FDA continues to monitor this signal, and the boxed warning remains as a precaution

The phase 2 trial data explicitly shows this is a bad idea

Current limited evidence does not suggest GLP-1 agonists worsen Crohn's disease, but their gastrointestinal side effects may complicate symptom monitoring

Unlike the combinatorial therapy of G-protein-coupled receptor-based peptide dual agonists, such as GLP-1/glucagon, these peptidyl nuclear hormone conjugates require additional consideration for differential pharmacodynamics where time action for clearance of each activity is inherently dissimilar