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They feel constantly thirsty because their body fluid losses overpower the central suppression

A meta-analysis involving more than 70,000 participants with type 2 diabetes (SMART-C) found that the cardiovascular benefits of SGLT-2 inhibitors, including reductions in MACE, cardiovascular death, hospitalisation for HF, and CKD progression, were consistent regardless of whether patients were receiving a GLP-1 receptor agonist at baseline [19]

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Clinical trials indicate a potential weight loss of up to 22.5%, which is impressive

A total of 225 participants were included in the modified intention-to-treat population and assigned to tirzepatide 10 mg ( n = 73), 15 mg ( n = 77), or placebo ( n = 75), alongside lifestyle modifications