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This finding was surprising in two ways: first, it is common for neurons to express receptors for their transmitter as a means to provide local negative feedback, but second, it also meant that the idea of peripheral GLP1 directly activating PPG neurons in order to convert a peripheral GLP1 signal into a central one was no longer tenable

[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Seino Y

The partial, Gs-biased signaling profile is well characterized structurally and pharmacologically, but its predicted clinical benefits (durability, tolerability) remain hypotheses

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Gut check on diabesity: leveraging gut mechanisms for the treatment of type 2 diabetes and obesity