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Acute changes in systemic glycemia gate access and action of GLP-1R agonist on brain structures controlling energy homeostasis

If you also need proven heart protection and you have type 2 diabetes with established cardiovascular disease, semaglutide (Ozempic) has an FDA indication for this benefit

B., Simpson R

The Gut Factor: Why You Need to Be Careful Beyond the brain, GLP-1s and GLP-1/GIPs (like tirzepatide) physically change how your digestion works

tirzepatide is contraindicated in individuals with personal or family history of medullary thyroid carcinoma or in patients with multiple endocrine neoplasia type 2 syndromes (54, 61)