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(2) What is the known safety profile of this combination in humans

If you develop a persistent, unexplained change in bowel habit particularly if you are aged 40 or over or have other risk factors your GP may wish to assess you in line with NICE guidance on suspected cancer (NG12), which sets out referral thresholds for persistent bowel changes

Side effects of longer treatment duration remain unclear

IGF-1 has a U-shaped relationship with health

One of the key benefits of Accutane is that it can provide long-term remission of acne
