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GLP-1R agonists improved renal biomarkers in placebo-controlled clinical studies, an effect supposed to be independent of the actions of these drugs on glycemic control
A suggested mechanism involves prolonged GIPR agonism causing receptor degradation, reducing sustained GIP signalling and, when combined with GLP-1R agonism, causing increased weight loss ( The GLP-1R has itself several LoF variants including R380C, shown by two independent groups to have normal surface expression but reduced affinity for Exenatide (Wootten et al., 2016
Improvements in cardiometabolic markers, such as blood pressure, cholesterol levels, and fasting blood sugar levels, are also likely to reverse when discontinuing a GLP-1
GLP-1 receptor agonists can be a game changer for weight loss
But then I had other colleagues who were working on obesity, and I was just kind of listening, right, what's going on there
