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Tirzepatides dual action can cause more frequent gastrointestinal side effects (nausea and diarrhea)

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140 However, diarrhea may be more pronounced with longer-acting formulations, and these differences should be factored into treatment selection and individualized care plans

Supporting gut health through diet may help maintain some benefits

Jennings says even those not on GLP-1s will benefit from smaller portions, saying it will reduce food waste, reduce the use of to-go containers and the trash that creates, and will promote a more cost-effective dining experience while still having portions that are appropriately sized