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Description
The main side effects of Ozempic are related to the gastrointestinal or digestive system
Orforglipron, an oral small-molecule GLP-1 receptor agonist for obesity treatment
It is suspected that they modulate miRNA involved in lipid metabolism, such as miR-200b, miR200c, miR-34a, miR-338, and miR-21, and induce activating lipid metabolic enzymes [131]
Historically described as mere fat-solubilizing agents, these amphipathic compounds were recently recognized as key signaling molecules capable to modulate the host metabolism directly acting as ligands of intestinal GPCRs (338, 339), or after being metabolized by the colonic microbiota into secondary bile acids, mostly deoxycholic and lithocholic acid(340)
E.et al (2021)
