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doi: 10.1186/s12888-022-042412
In December 2025, Eli Lilly announced positive topline results from TRIUMPH-4 a 68-week Phase 3 trial in adults with obesity and knee osteoarthritis in which retatrutide delivered average weight loss of up to 71.2 lbs alongside substantial reductions in osteoarthritis pain
Yet cardiomyocytes, the main muscle cells of the heart, and hepatocytes in the liver do not appear to express GLP-1 or GIP receptors in significant amounts
doi: 10.1002/micr.30855 6 ChangDWDayanJGreeneAKMacDonaldJKMasiaJMehraraBet al
While it may work better than some other weight loss medications, there are other factors to consider
