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doi: 10.1371/journal.pone.0115037

Thus, while up to 70% of PNA mice displayed irregular cyclicity, characterized by the appearance of only one generation of (mainly persistent regressing) corpora lutea, 100% of PNA mice treated with metformin showed regular ovarian cyclicity, denoted by the presence of two generations of corpora lutea, as a sign of preserved regular ovulations (Fig

However, our model also suggested that this third ureido residue could mimic the fourth amino acid residue (X4) by changing the substitution pattern (shift to the second methylene-C)