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Results Each propensity-score matched group constituted 3424 patients, 45% women, 21% had a history of cardiovascular disease, and 13.9% were treated with sodium-glucose cotransporter-2 inhibitors at baseline

However, the disparity between mechanistic promise and clinical maturity has direct implications for patient counselling, trial design, regulatory oversight, and ethical considerations surrounding the off-label and grey-market use of these therapies

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