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For people with type 2 diabetes and obesity, guidelines increasingly favor choosing GLP-1-based agents early in the treatment regimen, particularly when weight and cardiorenal risk are central goals

Responses to the less chartered topics will provide an insight into better and safer clinical practices

Another animal experiment suggested that GLP-1 and GLP-1R may be responsible for increased blood pressure and heart rate in response to stress

Gut-proglucagon-derived peptides are essential for regulating glucose homeostasis in mice

In addition to stimulating insulin secretion, these drugs can reduce glucagon production and peak postprandial glucose levels