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[22] Patients should consult their healthcare provider before starting any new medications

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In the tirzepatide group, TDD of insulin as well as basal and bolus insulin doses (expressed either in U/day or U/kg/day) decreased significantly from baseline and to a greater extent than in the semaglutide and control groups at all time points (least square mean TDD of insulin at 12 months: tirzepatide group, 26.4 U/day [0.13 U/kg/day]

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As it progresses, individuals may experience rapid heartbeat, low blood pressure, confusion, or even fainting