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Tirzepatide is an investigational once-weekly GIPR/GLP-1R dualagonist 14 with a profound therapeutic superiority in reducing blood glucose and body weight beyond several approved drugs such as semaglutide 15 and dulaglutide 16 in multiple head-to-head clinical trials

Jastreboff and colleagues (NEJM, 2023) reported substantial body-weight reduction in obesity research populations, and Rosenstock and colleagues (Lancet, 2023) documented glycemic and weight effects in type-2 diabetes research populations

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